Liquid Chromatography–Mass Spectrometry (LC–MS) is a technique that merges the physical separation of HPLC with the remarkable mass analysis capabilities of MS.
Liquid chromatography (LC) separates the sample components and then introduces them to the mass spectrometer (MS). The MS creates and detects charged ions. The ...
2021年5月17日 — LC-MS is an analytical technique that involves physical separation of target compounds (or analytes) followed by their mass-based detection.
The bottom-up proteomics LC–MS approach generally involves protease digestion and denaturation using trypsin as a protease, urea to denature the tertiary ...
由 SN Thomas 著作 · 2022 · 被引用 46 次 — TDM using LC-MS/MS offers the ability to characterize a patient's phenotype by measuring the parent and/or active metabolite concentrations with ...
2023年3月17日 — The 5 steps of LC/MS/MS · In the mass spectrometer, the quadrupoles filter separates ions based on their mass-to-charge ratios (m/z). · Ions and ...
由 JJ Pitt 著作 · 2009 · 被引用 1033 次 — LC-MS provides superior specificity and sensitivity compared to direct injection methods. When combined with stable isotope dilution, LC-MS can be used to ...